The Jonathan Boulter Memorial Lecture 2009
Department of Pathology,
University of Alabama,
Birmingham, USA
Wednesday, 7th October 2009
New Lecture Theatre, New Building, Heath Park
4:00 pm
"Th17: the discovery and emergence of a new T cell lineage"
(free wine reception after the lecture, room 1F09)
Thursday, 8th October 2009
Seminar Room UG16, Henry Wellcome Building, Heath Park
1:00 pm
"Developmental plasticity in the Th17 lineage:
implications for gene regulation"
(free lunch buffet from 12:40)
Download flyer here
Prof. Weaver is Professor of Pathology, Medicine and Microbiology. He received his BS and MD degrees from the University of Florida, and completed his residency and post-doctoral training at Barnes Hospital and Washington University. He was then an Assistant Professor in the Department of Pathology at Washington University until joining the University of Alabama at Birmingham in 1992.
The research in Prof. Weaver’s laboratory focuses on the mechanisms by which CD4 T cells control adaptive immunity. Major current projects concern the generation and characterization of transgenic and knock-in mouse models for tracking T cell fate during CD4 effector and memory T cell development; studies defining mechanisms that induce development of the Th17 effector lineage; the characterization of mechanisms by which dysregulation of CD4 T cells leads to inflammatory bowel disease; the delineation of the adhesion pathways that control effector T cell trafficking; and, the characterization of the genetic elements that regulate cytokine gene expression in Th1 and Th17 cells.
His seminal contributions to our understanding of CD4 T cell responses have been published in top journals including Nature, Nature Immunology, Immunity, and Journal of Experimental Medicine. His excellent reviews have featured in journals such as Annual Reviews in Immunology, Advances in Immunology, Current Opinions in Immunology, and Immunity.
Among his most recent publications, the two papers "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages" (Nature Immunology 2005) and "Transforming growth factor-ß induces development of the TH17 lineage" (Nature 2006) have already received >650 citations each.
The Jonathan Boulter Memorial Lecture is kindly supported by Miltenyi Biotec.